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EC number: 601-329-8
CAS number: 114798-26-4
Inhalation: Move into fresh air and keep at rest. For breathing difficulties, oxygen may be necessary. Get medical attention. If breathing stops, provide artificial respiration.
Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention.
Skin contact: Wash skin thoroughly with soap and water. Get medical attention if irritation persists after washing. Remove contaminated clothing and shoes. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.
Ingestion: Do not induce vomiting unless directed to do so by medical personnel. Never give liquid to an unconscious person. Contact physician if larger quantity has been consumed.
Most important symptoms and effects, both acute and delayed: No data available.
Indication of any immediate medical attention and special treatment needed:
Treatment: Treat supportively and symptomatically.
General fire hazards: Self-contained breathing apparatus and full protective clothing must be worn in case of fire.
Suitable extingishing media: Water spray, fog, CO2, dry chemical, or alcohol resistant foam.
Unsuitable extinguishing media: None known.
Special hazards arising from the substance or mixture: Emits toxic fumes under fire conditions.
Advice for firefighters:
Special Fire Fighting Procedures: No data available.
Special protective equipment for fire-fighters: Prevent runoff from fire control or dilution from entering streams, sewers, or drinking water supply.
Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Immediately contact emergency personnel. Keep unnecessary personnel away. Follow all fire fighting procedures.
Environmental precautions: Do not release into the environment.
Methods and material for containment and cleaning up: Small Liquid Spills: Absorb up with sand or other non-combustible absorbent material. Large quantities should not be discharged into the drain but removed with absorbing material. For waste disposal, see section 13 of the MSDS. Prevent runoff from entering drains, sewers, or streams.
Precautions for safe handling: Avoid breathing mists or vapors. Avoid exposure - obtain special instructions before use. Wash thoroughly after handling.
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a cool, well-ventilated place.
Specific end use(s): Pharmaceutical preparation.
Occupational exposure limits:
Chemical name Type Exposure Limit values Source
LOSARTAN FREE ACID TWA 0,1 mg/m3 Merck Occupational Exposure Band (OEB) or Wipe Test criteria
Wipe Test 1 mg/100 cm2 Merck Occupational Exposure Band (OEB) or Wipe Test criteria
OEB Category 2 is an internal Merck control band and corresponds to the 8-hour TWA (time-weighted average) and concentration of 0.1 - <1.0 mg / m3.
General information: Use feasible engineering controls to minimize exposure to compound.
Eye/face protection: Wear safety glasses with side shields (or goggles). If the work environment or activity involves dusty conditions, mists or aerosols, wear the appropriate goggles. Wear a faceshield or other full face protection if there is a potential for direct contact to the face with dusts, mists, or aerosols.
Hand protection: Chemical resistant gloves
Other: Work uniform or laboratory coat.
Respiratory Protection: Use an appropriate approved air-purifying respirator equipped with HEPA cartridges/canisters where there is the potential for exceeding established occupational exposure limits or occupational exposure bands. When handling a compound in solution, a cartridge/canister appropriate for the solution may also be needed. Use a positive pressure, air-supplied, pressure demand tight fitting respirator (e.g., SCBA or airline equipped with emergency escape bottle) where there is a potential for uncontrolled releases in excess of the respirator's capabilities, where exposure levels are unknown or where air-purifying respirators may not provide adequate protection.
Hygiene measures: Wash skin thoroughly with soap and water.
Reactivity: No data available.
Chemical stability: Stable
Possibility of hazardous reactions: Stable
Conditions to avoid: Moisture. Excessive heat.
Incompatible materials: None under normal conditions.
Hazardous decomposition products: Thermal decomposition or combustion may liberate carbon oxides and other toxic gases or vapors.
Waste treatment methods:
General information: Incineration is the most effective method of disposal in most instances. Do not allow runoff to sewer, waterway or ground. Operations that involve the crushing or shredding of waste materials or returned goods should take into account recommended exposure limits where they exist.
Disposal Methods: Disposal must be in accordance with applicable national, state/provincial, and/or local regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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