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EC number: 601-329-8
CAS number: 114798-26-4
The results for losartan potassium, which are read-across to losartan
free acid, are summarised below. Maternal toxicity occurred in the form
of three deaths and one abortion in the 40 mg/kg/day group, as well as
depressions in maternal body weight gain and food consumption. In
the 20 mg/kg/day group, there was one maternal death resulting in a
no-effect dose for maternal toxicity of 10 mg/kg/day.
Developmental toxicity occurred in the form of decreased fetal body
weight and delays in fetal ossification in the 40 mg/kg/day group
resulting in a no-effect dose for developmental toxicity of 20 mg/kg/day.
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