Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-329-8
CAS number: 114798-26-4
An acute oral toxicity study was conducted in four week old male mice
with L-158,086-005H. Five mice were used at each dose
level and were observed for a 48 hour observation period. Signs
of toxicity following the oral administration of the test compound were
ataxia, decreased activity, bradypnea and ptosis. The
signs were seen at the 3000 mg/kg dose level in ~15 minutes and at the
2308 mg/kg dose level within 90 minutes. No signs were
seen at lower doses. Deaths occurred in about 3 to 4.5
hours and were preceded by a loss of righting reflex. Surviving
mice appeared normal in 3 to 4 hours. On the second
day ataxia and bradypnea were seen at the 1775 mg/kg dose only and by
the end of the second day all survivors appeared normal.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again