Registration Dossier

Environmental fate & pathways

Phototransformation in water

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Administrative data

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Description of key information

Losartan is susceptible to aqueous photolysis and degrades rapidly under clear sky conditions. Two photodegradates are formed during photolysis; one less polar than the parent compound; one more polar than the parent compound. The maximum half-life for Losartan is less than 18 hours (at pH 9) in direct sunlight. The half-life at pH 7 was 11.8 hrs with a rate constant of 0.0587 / hr.  Therefore, by read-across, losartan free acid has a photolytical half life of <18hrs in aqueous conditions.

Key value for chemical safety assessment

Half-life in water:
18 h

Additional information