Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-329-8
CAS number: 114798-26-4
MK-0954 Free Acid was administered to five Wistar rats of each sex
by a single dermal application at 2000mg/kg body weight for 24 hours.
Animals were subjected to daily observations and weekly determination of
body weight. Macroscopic examination was performed after terminal
sacrifice (Day 15).
No mortality occurred.
Chromodacryorrhoea was noted in one male and one female on
Day 1. Scales and/or focal erythema was were seen in the treated
skin-area of two animals during the observation period.
The mean body weight gain during the observation period was
within the range expected for rats used in this type of study.
No abnormalities were found at macroscopic post mortem
examination of the animals.
The dermal LD50 value of MK-0954 Free Acid in Wistar rats was
established to exceed 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Na ovom portalu koristimo kolačiće kako bismo vam osigurali najbolje iskustvo njegova pregledavanja.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again