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EC number: 213-138-3
CAS number: 926-57-8
-Skin irritation/corrision: 1,3-dichlorobut-1-ene is corrosive to the skin of rabbits (Du Pont 1999, 1970, no guidelines followed)
OECD SIDS, 2007:
1,3-dichlorobut-1-ene was not a corrosive substance in the in vitro
International CorrositexTM assay (DuPont, 1999a). A follow-up in vivo
study was conducted in one rabbit to confirm this result. Two sites were
tested, one for 3 minutes and one for one hour. At the skin site treated
for 3 minutes with 1,3-dichlorobut-1-ene, mild erythema, but no edema
was noted. At 24 hours after test substance removal, moderate erythema
and moderate edema were observed. At 48 and 72 hours after test
substance removal, moderate erythema and severe edema were observed.
After a 1-hour exposure, moderate erythema and severe edema were
observed. Necrosis, severe erythema, severe edema, and a raw spot were
observed at 24, 48, and 72 hours after test substance removal.
Microscopic examination of the 3-minute test site revealed multifocal
minimal ulceration with degeneration of adjacent collagen and diffuse
mild epidermal hyperplasia. Microscopic examination of the 1-hour test
site revealed severe transmural necrosis with hemorrhage and edema
(DuPont, 1999b). Similar results were observed in a 24-hour dermal
irritation study with rabbits (DuPont, 1970).
Studies in Humans
On human epidermis, 1,3-DCB caused an itching and burning sensation in 3
minutes. At 6 minutes, the itching and burning sensation had vanished
and there was no skin inflammation (Roubal and Pokorny, 1943). No
information on the exposure conditions, number of individuals tested, or
test substance purity were available. In contrast to this report,
current plant site experience indicates that 1,3-DCB is irritating and
corrosive to human skin. Eye Irritation No eye irritation studies were
identified with 1,3-DCB but based on its corrosivity, 1,3-DCB is likely
to be severely irritating to the eyes.
1,3-DCB is corrosive to the skin of rabbits. Occupational experience
shows that 1,3-DCB is also irritating and corrosive to the skin, and
that 1,3-DCB vapour is irritating to the eyes and respiratory tract. No
eye irritation studies were identified with 1,3-DCB but based on its
corrosivity, 1,3-DCB is likely to be severely irritating to eyes
On the basis of the test results, 1,3-dichlorobut-2 -ene should be
classified as C, R34 according to DSD classification criteria and Skin
Corr. 1B, H314 (Causes severe skin burning) according to CLP
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