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Administrative data

Description of key information

-Acute toxicity: oral: LD50=414 mg/kg bw  (male rats); LD50=300 mg/kg bw (female rats) according to OECD TG 401
-Acute Toxicity: inhalation: LD50=546 ppm (male rats), no guideline followed

Key value for chemical safety assessment

Additional information

OECD SIDS, 2007:

Studies in Animals

Inhalation

The inhalation 4-hour LC50 of 1,3-DCB in the male rat ranged from 546 (Kwon and Waritz, 1968) to 756 ppm (2840 to 3930 mg/m³) (Barsegyan, 1969). At lethal levels, 1,3-DCB caused irregular breathing, lacrimation, salivation, and hyperemia of the ears. Histopathologic examination revealed hemorrhage of lungs, tracheitis, and cell degeneration in the liver, spleen, thymus, and lymph nodes; no changes were observed in the testes. Tubular degeneration of the kidneys was also noted (Kwon and Waritz, 1968). The 2-hour LC50 in the mouse was 846 ppm (4400 mg/m³) (Barsegyan, 1969).

Dermal

There are no rat or rabbit dermal LD50 studies available for 1,3-DCB.

Oral

The oral LD50 for 1,3-DCB was 300 and 414 mg/kg in fasted male and female rats, respectively (Bayer AG, 1991), and 1368 mg/kg in the non-fasted male rat (DuPont, 1982a). Clinical signs of toxicity included stained and wet fur, wet perineal area, diarrhea, weakness, hunched posture, alopecia, salivation, chromodacryorrhea, rough coat, sedation, and/or weight loss (Bayer AG, 1991; DuPont, 1982a). The pathology examinations of animals that died on study showed congested vessels of the stomach, reddened mucous membranes, reddened small intestine, and clear fluid in the stomach.

Studies in Humans

Inhalation

Exposure of workers to 1,3-DCB can cause dizziness and nausea (DuPont, 1993). Exposure details were not reported.

Conclusions

In rats, 1,3-DCB is acutely toxic via the inhalation and oral routes of exposure

Justification for classification or non-classification

On the basis of the test results the substance should be classified as Xn, R20/22 (Harmful; Harmful by inhalation and if swallowed) according to DSD, and Acute Tox 3 (Toxic if swallowed and if inhaled, H301, H331) according to CLP.