Registration Dossier

Administrative data

Endpoint:
specific investigations: nephrotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: MIGRATED DATASET. Original reference not translated, only short abstract available.

Data source

Reference
Reference Type:
publication
Title:
Gig. Tr. Prof. Zabol., (3):44-45
Author:
Petrosyan FR and Gizhlaryan MS
Year:
1985

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Enteric administration of 1,3-dichlorobut-2-ene to rats.
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
other: enteric
Vehicle:
water
Remarks:
2.5% of body weight
Doses / concentrations
Remarks:
Doses / Concentrations:
0.25 and 0.75 the LD50 of 1,3-dichlorobut-2-ene
Basis:

Results and discussion

Details on results:
After 72 hours, rats exposed to enteric administration of 0.25 and 0.75 the LD50 of 1,3-dichlorobut-2-ene and loading with water (2.5% of body weight) showed above normal diuresis. The biochemical data as well as histopathological observations indicated renal tubular damage. The necrotic nephrosis is apparently due to the inhibition of renal tubular SH-group containing enzymes.

Applicant's summary and conclusion