Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: MIGRATED DATASET. Original reference not available.

Data source

Reference
Title:
No information
Author:
Ibid., Mkheyan, V. E. (1959) (CA53:20537a).

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
dog

Results and discussion

Clinical signs:
Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked hemodynamic changes.
Body weight:
Dogs dermally treated with 1,3-dichlorobut-2-ene lost 42-45% of their initial body weight.
Other findings:
Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked histological changes in the brain, lungs, liver, kidney, pancreas, and thyroid.

Applicant's summary and conclusion