Registration Dossier
Registration Dossier
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EC number: 213-138-3 | CAS number: 926-57-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: MIGRATED DATASET. Original reference not available.
Data source
Reference
- Title:
- No information
- Author:
- Ibid., Mkheyan, V. E. (1959) (CA53:20537a).
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 1,3-dichlorobut-2-ene
- EC Number:
- 213-138-3
- EC Name:
- 1,3-dichlorobut-2-ene
- Cas Number:
- 926-57-8
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,3-dichlorobut-2-ene
Constituent 1
Test animals
- Species:
- dog
Results and discussion
- Clinical signs:
- Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked hemodynamic changes.
- Body weight:
- Dogs dermally treated with 1,3-dichlorobut-2-ene lost 42-45% of their initial body weight.
- Other findings:
- Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked histological changes in the brain, lungs, liver, kidney, pancreas, and thyroid.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
