Registration Dossier
Registration Dossier
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EC number: 213-138-3 | CAS number: 926-57-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: MIGRATED DATASET. Original reference not available.
Data source
Reference
- Title:
- No information
- Author:
- Ibid., Mkheyan, V. E. (1959) (CA53:20537a).
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 1,3-dichlorobut-2-ene
- EC Number:
- 213-138-3
- EC Name:
- 1,3-dichlorobut-2-ene
- Cas Number:
- 926-57-8
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,3-dichlorobut-2-ene
Constituent 1
Test animals
- Species:
- dog
Results and discussion
- Clinical signs:
- Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked hemodynamic changes.
- Body weight:
- Dogs dermally treated with 1,3-dichlorobut-2-ene lost 42-45% of their initial body weight.
- Other findings:
- Dogs dermally treated with 1,3-dichlorobut-2-ene, in addition to local effects, exhibited marked histological changes in the brain, lungs, liver, kidney, pancreas, and thyroid.
Applicant's summary and conclusion
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