1,3-dichlorobut-2-ene

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The effect of dichlorobutene on living organisms and its relation to occupational loss of hair observed in people working in the manufacture of chloroprene rubber.

Author:

Roubal J and Pokorny F

Year:

1943

Bibliographic source:

Casopia Lekaru Ceskych 82:901-20

Reference 2

Reference Type:

secondary source

Title:

1,3-Dichlorobut-2-ene - CAS No: 926-57-8

Author:

OECD SIDS

Year:

2007

Bibliographic source:

SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The dog was fed weekly 1 cc of 1,3-dichlorobut-2-en which was mixed with flour and given to the dog in a capsule so she would swallow it
whole. The dog was fed 2.5 cc 1,3-dichlrobut-2-ene in the first 20 days.

GLP compliance:

no

Remarks:

GLP was not mandatory at the time of the study

Test material

Test material information

Constituent 1

Reference substance name:

1,3-dichlorobut-2-ene

EC Number:

213-138-3

EC Name:

1,3-dichlorobut-2-ene

Cas Number:

926-57-8

Molecular formula:

C4H6Cl2

IUPAC Name:

1,3-dichlorobut-2-ene

Constituent 2

Reference substance name:

EC number: 213-138-3

IUPAC Name:

EC number: 213-138-3

Test animals

Species:

dog

Strain:

other: Mixed black-white fox-terrier

Sex:

female

Administration / exposure

Route of administration:

oral: capsule

Details on oral exposure:

DIET PREPARATION
- Rate of preparation of diet (frequency): 1 cc of 1,3-DCB which was mixed with flour and given to the dog in a capsule

Duration of treatment / exposure:

1 month

Frequency of treatment:

once a week

Doses / concentrations

Remarks:

Doses / Concentrations:
1 cc (weekly), 2.5 cc (during first 20 days)
Basis:

No. of animals per sex per dose:

1

Control animals:

no

Results and discussion

Results of examinations

Details on results:

One hour and half after feeding, a light glassy slime returned, very viscous with an odour of 1,3-dichlorobut-2-ene. During the first week a kilo of weight was lost and at the end of the same week the hair began to fall in considerable amounts. The dog was fed 2.5 cc of 1,3-dichlorobut-2-ene in the first 20 days. The maximum loss of hair was noticed than. The gastric juices after a month feeding had a high free acid amount and a total of acidity of 106.4 which indicates an inflammation of the mucous membrane of the stomach. The tongue at the time was very dry. After a month the test was terminated, the fur began to grow fast, in good quantity and it was of glossy appearance. After 2 months from the beginning of the test the dog weighed 10.5 K.

Target system / organ toxicity

Critical effects observed:

not specified