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EC number: 204-781-0 | CAS number: 126-30-7
The test substance is not irritant to the rabbit skin.The instillation of the test substance resulted in serious damage to the eyes. Effects may be simply due to a mechanical particle effect. However a chemical action of the substance can not be excluded.
In a valid OECD Guideline study (OECD 404, adopted 1981) six rabbits were dermally exposed to 0.5 g neopentyl glycol (grinded and moistened with paraffin oil) for 4 h. Patches were removed and skin washed with water. Erythema and edema scores were read 1, 24, 48 und 72 h after patch removal and after 6, 8, 10, and 14 days. The max. mean score for erythema was 0.66 24 h after patch removal and for edema 0.33 24 and 48 h after removal (Huels 1985). In conclusion, only slight irritant effects to the skin of rabbits were induced; the test substance is not irritant to the skin.
Similar results were reported by BASF AG (1982; comparable to OECD Guideline 404 with acceptable restrictions). No edema (score 0) and no erythema (score 0) was detected in any rabbit at any time point.
In a study conducted according to OECD Guideline 405 (adopted 1981; Huels 1985) 3 male and 3 female rabbits received instillations of ca. 100 mg crystalline test substance into the left conjunctival sac, the right eye was untreated (control). Scoring according to the Guideline was performed 1, 24, 48, and 72 hours and 6, 8, 10, 13, 17 and 21 days after instillation. The first 72 h after instillation necrosis of nictitating and mucous membrane of the conjunctivae of all 6 rabbits were reported. At termination (day 21) irreversible damage in 2 out of 6 rabbits was obvious: opacity of the cornea (grading score 2, area involved score 2) accompanied by circumcorneal injection and iritis. Effects may be simply due to a mechanical particle effect. However a chemical action of the substance can not be excluded.
Conclusion: The instillation of the test substance resulted in serious damage to the eyes.
Data from two independent studies suggested that no classification and labelling according to EC Regulation No. 1272/2008 or
EU Directive 67/548/EEC is required.
Induces serious damage to the eyes. The criteria for classification of EU Directive 67/548/EEC and Regulation (EC) No. 1272/2008 are met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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