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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets scientific standards with acceptable restrictions (partly limited documentation, e.g. no details about test substance, post exposure observation period).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report Date:
1958

Materials and methods

GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no details

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
no details

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
1, 2, 3.2, 4, 6.3, 10 g/kg bw
No. of animals per sex per dose:
up to 5 rats
Details on study design:
no further details
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
2 800 mg/kg bw
Mortality:
0/1, 0/5, 4/5, 5/5, 1/1, 1/1, 1/1 at 1, 2, 3.2, 4, 6.3, 8, 10 g/kg bw, respectively
Clinical signs:
slight to deep narcosis within short time

Any other information on results incl. tables

No further details

Applicant's summary and conclusion

Conclusions:
LD50 in rats after i.p. injection was ca. 2800 mg/kg bw.
Executive summary:

Study meets scientific standards with acceptable restrictions (partly limited documentation, e.g. no details about test substance, post exposure observation period).

The acute toxicity in female rats after i.p. injection was studied. Slight to deep narkosis within short time after application was observed. LD50 in rats after i.p. injection was ca. 2800 mg/kg bw.