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EC number: 203-570-0
CAS number: 108-30-5
The percutaneous absorption of
hexahydrophthalic anhydride was very low following application to the
skin of three human volunteers. Cyclic anhydrides, such as
hexahydrophthalic acid, are readily hydrolyzed to the corresponding
dicarboxylic acids and the excreted amounts of hexahydrophthalic acid in
the three volunteers were between 0% and 4.5% of the total applied dose.
The subject with the highest excretion showed mild skin effects which
suggested that inflamed skin may permit higher dermal absorption.
Cyclic anhydrides share structural and
physicochemical properties such that toxicokinetic data on
hexahydrophthalic anhydride can be used to read-across to succinic
anhydride. The hydrolysis product of succinic anhydride is succinic
acid, an endogenous substance and food ingredient, that is expected to
show minimal absorption by the dermal route. A separate percutaneous
absorption study on succinic anhydride is not proposed and cannot be
justified based upon animal welfare considerations.
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