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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Succinic anhydride
EC Number:
203-570-0
EC Name:
Succinic anhydride
Cas Number:
108-30-5
Molecular formula:
C4H4O3
IUPAC Name:
succinic anhydride

Test animals

Species:
rat

Results and discussion

Applicant's summary and conclusion

Conclusions:
Negative results on genotoxic effects were obtained from the in vivo chromosome aberration test in rat bone marrow cells.
Executive summary:

A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.

Result of the rat bone marrow cells (chromosome aberrations in vivo) was negative - no genotoxic effects