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EC number: 203-570-0
CAS number: 108-30-5
Mutagenicity of succinic anhydride in Salmonella typhimurium (Laboratory
Table 2. Mutagenicity of succinic anhydride
in Salmonella typhimurium (Laboratory 2)
a reverse gene mutation assay in bacteria performed similar to OECD 471,
TA 97, TA98, TA100, TA1535 and TA1537 strains of Salmonella typhimurium
were exposed to Succinic acid (99.9% purity) in DMSO at concentrations
of 0, 3, 10, 33, 100, 333, 666, 1000, 3333 and 10000 µg/plate by a
preincubation protocol in the presence and absence of metabolic
activation via Aroclor 1254 -induced male Sprague Dawley rat or Syrian
hamster liver S9.
anhydride was tested up to concentrations causing cytotoxicity or
exceeding the recommended limit concentration. The
positive controls induced the appropriate responses in the corresponding
There was no evidence of induced mutant
colonies over background in any of the strains tested. Based on these
results, Succinic anhydride is not considered to be mutagenic in
The study is classified as acceptable.
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