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EC number: 203-570-0
CAS number: 108-30-5
Review of data summarized, based on 5
summary of studies on cyclic anhydrides demonstrate that cyclic acid
anhydrides display low systemic bioavailability after dermal exposure
but increased absorption rates after inhalation exposure (> 85% of
inhaled dose). Cyclic acid anhydrides bind to plasma proteins and
haemoglobin and the primary binding amino acid appears to be lysine. The
half-time of methyl hexahydropthalic anhydride adducts was 20 days.
Cyclic acid anhydrides are hydrolysed to corresponding dicarboxylic
acids and effectively excreted in urine. The urinary half-time for the
dicarboxylic acid of phthalic anhydride was 14 h, whereas half-times for
the dicarboxylic acids of hexahydrophthalic anhydride, methyl
hexahydrophthalicanhydride, and methyl tetrahydrophthalic anhydride were
generally shorter (between 2 and 7 h).
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