Registration Dossier
Registration Dossier
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EC number: 236-921-1 | CAS number: 13548-38-4
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: CrCl3, a structural analogue of chromic nitrate, can be used for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- Concise International Chemical Assessment Document 76 INORGANIC CHROMIUM(III) COMPOUNDS
- Author:
- Dr Tiina Santonen, Dr Antti Zitting, and Dr Vesa Riihimäki
- Year:
- 2 009
- Bibliographic source:
- International Programme on Chemical Safety (IPCS)
Materials and methods
- Type of study / information:
- in vivo
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- chromium chloride
- IUPAC Name:
- chromium chloride
- Test material form:
- not specified
- Details on test material:
- The median diameter of the aerosol particles was 1.2 µm.
Constituent 1
Results and discussion
Any other information on results incl. tables
Enzymatic and cytological profiles of lung lavage fluids were examined. At the higher exposure concentration, a slight increase in lysosomal enzymes was found 1 day after exposure, and a slight increase in acid phosphatase was found throughout the study (i.e. for 21 days). Histopathological examination at day 1 after exposure showed focal accumulations of macrophages, and the alveolar capillaries were diffusely congested. The authors considered these responses to be minimal.
Applicant's summary and conclusion
- Conclusions:
- Chromium chloride can cause irritation to hamster's respiratory.
- Executive summary:
The respiratory irritancy of chromium chloride was studied by exposing Syrian hamsters to nebulized liquid aerosols of chromium(III) chloride at 2.8 or 77 mg/m3 for 0.5 h.
Enzymatic and cytological profiles of lung lavage fluids were examined. At the higher exposure concentration, a slight increase in lysosomal enzymes was found 1 day after exposure, and a slight increase in acid phosphatase was found throughout the study (i.e. for 21 days). Histopathological examination at day 1 after exposure showed focal accumulations of macrophages, and the alveolar capillaries were diffusely congested. The authors considered these responses to be minimal.
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