Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-138-0
CAS number: 36631-30-8
A bacterial reverse mutation assay (Ames test) showed that
read-across substance, tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate,
does not induce reverse mutations in Salmonella typhimurium or
Potential mutagenic activity has been examined by assaying for the
induction of 5‑trifluorothymidine resistant mutants in mouse lymphoma
L5178Y cells after in vitro treatment. The read-across substance,
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate, did not induce
mutations in mouse lymphoma L5178Y cells.
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate, was assayed for the
ability to cause chromosomal damage in cultured human lymphocytes,
followingin-vitrotreatment in the absence and presence of S9
metabolic activation. The
substance did not induce chromosomal aberrations in human lymphocytes
after in-vitro treatment.
REACH Regulation 1907/2006 (Annex VIII, 8.4 Column 2) states that
appropriate in-vivo mutagenicity studies should be considered in those
cases of a positive result in any of the in vitro genotoxicity studies.
In vitro investigations were negative and in vivo studies are therefore
regarded as inappropriate and not in line with current concerns
regarding animal welfare and the use of animals in scientific
The above studies have all been ranked reliability 1 according to the
Klimisch et al system. This ranking was deemed appropriate because the
studies were conducted to GLP and in compliance with agreed protocols.
Sufficient dose ranges and numbers are detailed; hence it is appropriate
for use based on reliability and animal welfare grounds.
By read-across, the above results triggered no classification under the
Dangerous Substance Directive (67/548/EEC) and the CLP Regulation (EC No
1272/2008). No classification for genetic toxicity is
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again