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EC number: 253-138-0
CAS number: 36631-30-8
The substance was shown to be not readily
biodegradable in a study according to OECD Guideline 301B. Consequently,
the test substance is likely to have a
half-life in marine water higher than 60 days or a half-life in fresh
water higher than 40 days therefore the substance is considered to be
Based on the results of the bioaccumulation study in fish with a closely
related structural analogue and the QSAR modelling, the BCF value for
the test substance is estimated to be 4.1 L/kg ww (geometric mean),
which is well below the threshold value quoted in the REACH Regulation
of 2000 or 5000 which indicates the potential to bioaccumulate. The
substance is therefore not considered to be “bioaccumulative” or “very
bioaccumulative” on the basis of the available data.
In a long-term fish toxicity study with a
closely related structural analogue, tris(2-ethylhexyl)
benzene-1,2,4-tricarboxylate, the 14 day NOEC was determined to be >75.0
mg/L. A NOEC value of 55.6 mg/L was obtained in a Daphnia 21-day
reproduction study with the same closely related analogue.
mutagenicity of closely related structural analogue,tris(2-ethylhexyl)
was evaluated in three in vitro assays with and without metabolic
activation. All endpoints demonstrated a lack of mutagenic response.
reproduction/developmental screening test using read-across substance,
1,2,4 -benzenetricarboxylic acid, trioctyl ester, provided a NOAEL value
of 500 mg/kg bw/day and showed no treatment-related effects on parents
No carcinogenicity studies have been conducted, however, there is
no evidence from the repeated dose toxicity studies to suggest that the
substance is carcinogenic.
repeated dose toxicity study conducted with read-across substance,tris(2-ethylhexyl)
benzene-1,2,4-tricarboxylate, provided a NOAEL value of 225 mg/kg bw/day.
The substance is not classified on the basis of this data and no further
toxicological examination is considered necessary for hazard assessment.
Therefore, the substance does not fulfil the requirements of Annex
XIII, Para 1.3 based on evaluation of available data, and cannot be
considered as “T” for the purposes of the assessment.
Summary and overall Conclusions on PBT or vPvB Properties
The substance cannot be considered to fulfil all the criteria for
Persistence, Toxicity or Bioaccumulation, as specified in REACH Annex
XIII. As such, the substance cannot be considered a PBT or vPvB
substance, based on the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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