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EC number: 253-138-0
CAS number: 36631-30-8
In Assay 1, using the plate incorporation method, the substance
was tested at the maximum concentration of 5000 μg/plate and at four
lower concentrations. No relevant toxicity was observed with any tester
strain at any dose-level. No relevant increase in revertant numbers was
observed at any concentration tested. A pre-incubation step was included
for all treatments of Assay 2 in which the same concentrations were
employed. No toxicity was observed at any dose-level with any tester
No precipitation of the test item was observed at the end of the
incubation period at any concentration in the plate incorporation
experiment or in the pre-incubation experiment.
The substance did not induce increases in the number of revertant
colonies in the plate incorporation or pre-incubation assay, at any
dose-level, in any tester strain, in the absence or presence of S9
The sterility of the S9 mix and the test solutions was confirmed
by the absence of colonies on additional agar plates spread separately
with these solutions. Marked increases in revertant numbers were
obtained in these tests following treatment with the positive control
items, indicating that the assay system was functioning correctly.
A bacterial reverse mutation assay (Ames test) has been undertaken
following OECD/EU test methods.
The read-across substance, tris(2-ethylhexyl)
benzene-1,2,4-tricarboxylate, does not induce reverse mutation in Salmonella
typhimurium or Escherichia coli.
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