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Density

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Reference
Endpoint:
density, other
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23-07-2018 – 23-07-2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density of Test item tetrasodium 7-amino-4-hydroxy-3-[(E)-2-{2- methoxy-5-methyl-4-[2-(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1-yl] -8-[(E)-2-{2-sulfonato- 4-[2-(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1-yl]naphthalene-2-sulfonate (CAS No.503155-49-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.
GLP compliance:
no
Type of method:
pour and tap (for solids)
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material : 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-3-[[2-methoxy-5-methyl-4-[[2-(sulfooxy)ethyl]sulfonyl] phenyl]azo]-8-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-, tetrasodium salt
- Molecular formula : C28H25N5Na4O20S6
- Molecular weight : 1035.87 g/mol
- Smiles notation : Cc1cc(N=Nc2c(S(=O)(=O)O{-}.[Na]{+})cc3c(ccc(N)c3N=Nc3ccc(S(=O)(=O)CCOS(=O)(=O)O{-}.[Na]{+})cc3S(=O)(=O)O{-}.[Na]{+})c2O)c(OC)cc1S(=O)(=O)CCOS(=O)(=O)O{-}.[Na]{+}
- Substance type : Organic
- Physical state : Solid
Key result
Type:
pour density
Density:
0.488 g/cm³
Temp.:
25 °C
Remarks on result:
other: 964.65 hPa..
Key result
Type:
tap density
Density:
0.742 g/cm³
Temp.:
25 °C
Remarks on result:
other: 964.65 hPa..

S. No.

Method Details

Observed Values

1stObservation

  2ndObservation

1.                   

Guideline

OECD 109

 

 

2.                   

Method

Test methods: Pour density

and tapped density of

powders” recommended in

The International

Pharmacopoeia, Fourth

Edition, 2014

3.                   

Principle of Method

Pour Density: It is the ratio

of known weight of test item

and its volume in graduated

glass cylinder.

Tap Density: It is the

difference between the

volume of test item

measured before & after

tapping in the graduated

glass cylinder.

 

 

4.                   

Test temperature    

(°C)

25oC

25oC

5.                   

Atmospheric pressure

(hPa)

965.2 hPa

964.1 hPa

6.                   

Weight of test

item(m)

g

 20.006 g

20.004 g

7.                   

Volume of measuring

cylinder; readability

in g

 250;2ml

 250;2ml

8.                   

Volume of test item

without tapping (V)

 40

 42

9.                   

Volume of test item

after tapping ( V1)

After 10 tapping

 30

 30

10.               

After 50 tapping

 28

 26

11.               

After 100 tapping

 28

 26

12.               

After 250 tapping

Conclusions:
The density of Test item tetrasodium 7 -amino-4 -hydroxy-3 -[(E)-2 -{2 -methoxy-5 -methyl-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]-8 -[(E)-2 -{2 -sulfonato-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]naphthalene-2 -sulfonate (CAS No.503155-49-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.
Executive summary:

The density of Test item tetrasodium 7 -amino-4 -hydroxy-3 -[(E)-2 -{2 -methoxy-5 -methyl-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]-8 -[(E)-2 -{2 -sulfonato-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]naphthalene-2 -sulfonate (CAS No.503155-49-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.

Description of key information

The density of Test item tetrasodium 7 -amino-4 -hydroxy-3 -[(E)-2 -{2 -methoxy-5 -methyl-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]-8 -[(E)-2 -{2 -sulfonato-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]naphthalene-2 -sulfonate (CAS No.503155-49-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.

Key value for chemical safety assessment

Additional information

The density of Test item tetrasodium 7 -amino-4 -hydroxy-3 -[(E)-2 -{2 -methoxy-5 -methyl-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]-8 -[(E)-2 -{2 -sulfonato-4 -[2 -(sulfonatooxy)ethanesulfonyl]phenyl}diazen-1 -yl]naphthalene-2 -sulfonate (CAS No.503155-49-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.