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Physical & Chemical properties

Density

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Reference
Endpoint:
density, other
Remarks:
pour and tap density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Qualifier:
according to guideline
Guideline:
other: method recommended in the International Pharmacopoeia, fourth Edition, 2014
GLP compliance:
no
Type of method:
pour and tap (for solids)
Key result
Type:
pour density
Density:
0.488 g/cm³
Temp.:
25 °C
Remarks on result:
other: at 964.65 hPa
Key result
Type:
tap density
Density:
0.742 g/cm³
Temp.:
25 °C
Remarks on result:
other: at 964.65 hPa

TEST ITEM DESCRIPTION AND RESULTS :

FOR SOLIDS:

By Pour Density and Tapped Density Method:

    Method Details     Observations

 Remarks if, any

 Guideline

 OECD 109

1st Reading

 2nd Reading

                                        

 Method

 Test methods: Pour density

and tapped density of

powders” recommended in

The International

Pharmacopoeia, Fourth

Edition, 2014

 

 

 Principle of method

 Pour Density: It is the ratio

of known weight of test item

and its volume in graduated

glass cylinder.

Tap Density: It is the

difference between the

volume of test item

measured before & after

tapping in the graduated

glass cylinder.

 

 

 Test temperature (°C)

 

25 °C

 25°C

 Atmospheric

pressure (in hPa)

 

965.2 hPa 

 964.1 hPa

Weight of test

item(m)

 

 20.006

20.004 

 Volume of measuring

cylinder; readability

in ml

 

250 ml;2ml 

 250 ml;2ml

 Volume of test item

without tapping (V)

 

 40

42 

 Volume of test item

after tapping ( V1)

After 10 tapping 

 30

30 

   After 50 tapping 28  26 
   After 100 tapping 28   26
   After 250 tapping  -  -
   After 500 tapping  -
   After 750 Tapping  -

*ρat=density of air at 27°C and 760 mm Hg pressure= 0.001168 g/cm³

CALCULATIONS:

FOR SOLIDS:

By Pour Density and Tapped Density Method:

    Parameters Details         Calculated values

Average

Density

    

 1st

Calculation

2nd

Calculation

 Pour Density of test Item

(g/cm³)

= m

V

 

 0.5001

 0.4762

 0.4882

 Tap density of test Item

(g/cm³)

= m

V1

 

 0.7145

 0.7693

 0.7419

Conclusions:
The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014 . The mean pour density and tapped density of the test chemical was determined to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.
Executive summary:

The density of test chemical was determined following OECD Guideline 109 (Density of Liquids and Solids) and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014 . The mean pour density and tapped density of the test chemical was determined to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.

Description of key information

On the basis of available data from study report, the density of test chemical was determined following OECD Guideline 109 (Density of Liquids and Solids) and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.

Key value for chemical safety assessment

Relative density at 20C:
0.488

Additional information

On the basis of available data from study report, the density of test chemical was determined following OECD Guideline 109 (Density of Liquids and Solids) and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.4882 g/cm³ and 0.7419 g/cm³ at 25°C and 964.65 hPa.