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EC number: 610-522-6
CAS number: 503155-49-5
Table 1: Acute Oral Toxicity study
*T = Tokyo Kasei Kogyo Industry
Ltd., Tokyo, Japan;
** In order to set appropriate
doses for the assay, we determined approximate LD50 by simple acute
toxicity experiments on four–five animals. When no death was observed at
2000 mg/kg, the LD50 was defined as >2000 mg/kg.
Acute oral toxicity experiment was
conducted prior to Comet assay in male DDY mice. Male ddY mice were
obtained from Japan SLC Co., Shizuoka, Japan, at 7 weeks of age and used
after 1 week of acclimatization. They were fed commercial pellets MF
(Oriental Yeast Industries Co., Tokyo, Japan) and tap water ad libitum
throughout the acclimatization period and the experiment. The animal
room was kept at 20–24°C with a 12 h light – dark cycle. In order to set
appropriate doses for the assay, the approximate LD50 was determined by
simple acute toxicity experiments on four–five animals. When no death
was observed at 2000 mg/kg, the LD50 was defined as >2000 mg/kg. The
acute oral LD50 in male DDY mice was determined to be greater than 2000
mg/kg after dosing with test chemical.
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