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EC number: 204-649-2
CAS number: 123-76-2
The corneal damage potential of the
substance was assessed by quantitative measurements of changes in
opacity and permeability in a bovine cornea, according to the OECD
Guideline 437. The test item was brought onto the cornea of a bovine eye
which had been incubated with cMEM without phenol red at 32 ± 1 °C for 1
hour and whose opacity had been measured. The test item was incubated on
the cornea for 10 minutes at 32 ± 1 °C. After removal of the test item
and 2 hours post-incubation, opacity and permeability values were
Under the conditions of this study, the
test item induced serious eye damage on the cornea of the bovine eye.
The calculated IVIS (in vitro irritancy score) was 84.29 which is within
the range for classification (according to the classification criteria
of OECD 437) of the substance as causing serious eye damage.
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