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EC number: 223-267-7
CAS number: 3794-83-0
Table 1 Summary of deaths in LD50 determination study.
In a well conducted, non-GLP study, 5000 mg/kg bw undiluted Dequest 2016
was given to five Sprague-Dawley rats by oral gavage in a limit test.
Within seven hours all of the animals had died. Therefore a
range-finding study and subsequent LD50 determination were
performed. In the range-finding study, doses of 50, 100, 500, 1000 and
2000 mg/kg bw were administered to one male and one female
Sprague-Dawley rat. Based on the findings of this study, doses of 2000,
2500, 3200 and 4000 mg/kg bw Dequest 2016 were administered to
Sprague-Dawley rats (5/sex) by oral gavage. Animals were observed for 14
days following dosing, and all animal were examined macroscopically.
Body weights were recorded before dosing and on days 7 and 14. One, 4, 7
and 8 animals died, respectively. Observations in all groups for up to
four hours post-dosing, included ataxia and/or tremors, oral and nasal
discharge, hypoactivity, soft stool and fecal and/or urinary
staining. The majority of surviving animals showed some weight loss
during the first week after dosing, but all animals then gained weight
between days 7 and 14.
Macroscopic abnormalities observed at necropsy were
primarily changes to the lungs (discolouration) and
gastrointestinal tract (red or black walls, or red or black
fluid present, suggestive of an irritant effect). Most of the
animals in the 2500, 3200 and 4000 mg/kg dose groups had enlarged
kidneys at necropsy, and one animal in the 4000 mg/kg bw group had
unilateral renal pallor, dilated renal pelvis and red fluid surrounding
the kidney. The LD50 was calculated to be 2850 mg/kg bw
(subsequently calculated to be equivalent to 940 mg active salt/kg bw).
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