Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
223-267-7
CAS no.:
3794-83-0
Index number:
Molecular formula:
C2H8O7P2.4Na
SMILES:
[Na+].[Na+].[Na+].[Na+].CC(O)(P([O-])([O-])=O)P([O-])([O-])=O
InChI:
InChI=1S/C2H8O7P2.4Na/c1-2(3,10(4,5)6)11(7,8)9;;;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;;;/q;4*+1/p-4
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
16
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is harmful if swallowed and causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause long lasting harmful effects to aquatic life and causes skin irritation.

Breakdown of all 566 C&L notifications submitted to ECHA

Eye Irrit. 2 H319
Acute Tox. 4 H302
Skin Irrit. 2 H315
Aquatic Chronic 4 H413
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, coating products, fertilisers, water softeners, cosmetics and personal care products, air care products and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal), industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting) and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints) and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: water softeners, washing & cleaning products, air care products, coating products, fertilisers, polishes and waxes and cosmetics and personal care products.

This substance is used in the following areas: agriculture, forestry and fishing and building & construction work.

This substance is used in the following activities or processes at workplace: transfer of chemicals, non-industrial spraying, hand mixing with intimate contact only with personal protective equipment available, roller or brushing applications, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and mixing in open batch processes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: pH regulators and water treatment products and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: water softeners, pH regulators and water treatment products, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and mining. This substance is used for the manufacture of: textile, leather or fur, pulp, paper and paper products, metals, fabricated metal products, machinery and vehicles and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, closed batch processing in synthesis or formulation and industrial spraying.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, laboratory work and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and in processing aids at industrial sites.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Shandong Taihe Water Treatment Technologies Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Covance Clinical Development SA 016, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Ecolab Production Netherlands B.V., Brugwal 11 3432 Nieuwegein Netherlands
  • Italmatch Chemicals SpA - OR 1, Via Magazzini del Cotone 17 – modulo 4 16128 genova Italy
  • McBride S.A.S., Rue Victor Hugo 109/111 92300 Levallois-Perret France
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • RIHASSAS-CONSULTING, Rotterdamer Str. 5 50735 Köln NRW Germany
  • Trifor Blending &filling services bv, Butaanweg 7A 3196 KC Vondelingenplaat Rt Netherlands
  • ZSCHIMMER & SCHWARZ MOHSDORF GmbH & Co KG, Chemnitztalstraße 1 09217 BURGSTÄDT Germany
  • Airedale Chemical Company Ltd, Skipton Road Cross Hills BD20 7BX Keighley West Yorkshire United Kingdom
  • Cytec Industries BV OR for UK, Burgemeester van Lierplein 75 3134 ZB Vlaardingen Netherlands
  • Robert McBride Ltd, Middleton Way Middleton M24 4DP Manchester United Kingdom

Substance names and other identifiers

(1-Hydroxyethylidene)bisphosphonic acid, tetrasodium salt
Other
(1-Hydroxyethylidene)diphosphonic acid, tetrasodium salt
Other
1-Hydroxyethylidene-1,1-diphosphonic acid, tetrasodium salt
Other
Defloc EN 43
Other
Dequest 2016
Other
Diphosphonic acid, (1-hydroxyethylidene)-, tetrasodium salt
Other
Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt
Other
Phosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium salt
Other
Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:4)
Other
Sequion 10Na4
Other
Tarpinel 4NL
Other
Tetrasodium (1-hydroxyethylidene)bisphosphonate
EC Inventory, REACH pre-registration
Tetrasodium (1-hydroxyethylidene)bisphosphonate
REACH pre-registration, Other
Tetrasodium 1-hydroxyethane-1, 1-diphosphonate
Other
Tetrasodium 1-hydroxyethylidene-1,1-diphosphonate
Other
Tetrasodium etidronate
Other
Turpinal 4NL
Other
Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:4)
Other
1-Hydroxyethylidene-1,1-diphosphonic acid
C&L Inventory
Etidronic Acid, Tetrasodium Salt
Registration dossier
HEDP 4Na
Registration dossier
HEDP-4Na
Registration dossier
HEDP-xNa Update
Registration dossier
Hydroxyethylidene-1,1-diphosphonic acid tetrasodium salt
C&L Inventory
PHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)BIS-, TETRA SODIUM SALT
C&L Inventory
Phosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium salt
C&L Inventory
Phosphonic acid,P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:4)
C&L Inventory
sodium hydrogen (1-hydroxy-1-phosphonoethyl)phosphonate
Registration dossier
Tetra sodium (1-hydroxyethylidene)bisphosphonate
Registration dossier
tetrasodium (1-hydroxy-1-phosphonatoethyl)phosphonate
C&L Inventory, Registration dossier
tetrasodium (1-hydroxy-1-phosphonoethyl)phosphonate
Registration dossier, Other
tetrasodium (1-hydroxyethane-1,1-diyl)bis(phosphonate)
C&L Inventory, Registration dossier
Tetrasodium (1-hydroxyethylidene) biphosphonate
C&L Inventory
Tetrasodium (1-hydroxyethylidene)bisphosphonate
C&L Inventory, Registration dossier
Tetrasodium (1-hydroxyethylidene)bisphosphonate
C&L Inventory, Registration dossier
tetrasodium (1-hydroxyethylydene)bisphosphonate
C&L Inventory
tetrasodium 1,1-diphosphonatoethanol
C&L Inventory
tetrasodium(1-hydroxyethane-1,1-diyl)bis(phosphonate)
C&L Inventory
tetrasodium;1,1-diphosphonatoethanol
Other
Airquest C
Registration dossier
Briquest ADPA-20AS
Registration dossier
Briquest ADPA-21SH
Registration dossier
Briquest ADPA-60SH
Registration dossier
CUBLEN K 3014
Registration dossier
CUBLEN K 8514 GP
Registration dossier
CUBLEN K 8514 GR
Registration dossier
Haphonat HNA G (HEDP) techn.
C&L Inventory
HEDP-4NA
Registration dossier
104365-97-1
CAS number
Other
104365-97-1
Deleted CAS number
Other
146437-16-3
CAS number
Other
146437-16-3
Deleted CAS number
Other
3794-83-0
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
863638-08-8
CAS number
Other
863638-08-8
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Data not provided by the registrant

Melting/freezing point

Data not provided by the registrant

Boiling point

Data not provided by the registrant

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.53 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Data not provided by the registrant

Partition coefficient

Data not provided by the registrant

Water solubility

Data not provided by the registrant

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Data not provided by the registrant

Flash point

Data not provided by the registrant

Auto flammability

Data not provided by the registrant

Flammability

Data not provided by the registrant

Explosiveness

Data not provided by the registrant

Oxidising

Data not provided by the registrant

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Data not provided by the registrant

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Data not provided by the registrant

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Data not provided by the registrant

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Data not provided by the registrant

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Data not provided by the registrant

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Data not provided by the registrant

Irritation / corrosion

Data not provided by the registrant

Sensitisation

Data not provided by the registrant

Repeated dose toxicity

Data not provided by the registrant

Genetic toxicity

Data not provided by the registrant

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant