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EC number: 223-267-7
CAS number: 3794-83-0
1: Effect of D2010 on growth and survival of D. magna after 28 days
(average of 4 replicates).
Nominal concentrations (mg/L as active acid)
Mortality of parents
Cumulative number of offspring
4.3 ± 1.0
0.75 ± 0.5
3.2 ± 0.9
4.5 ± 0.5
4.2 ± 0.1
Result expressed as nominal concentration. Properties of the
test substance and evidence from other studies where
concentrations were measured indicate that nominal and measured concentrations are likely to be in good agreement.
Not enough information is reported on water
quality, however the frequency of water renewal suggests the parameters
to be in acceptable ranges.
(28 d) NOEC 9.63 mg/L D. magna (r-a)
28 day NOEC value of 6.75 mg/L has been determined for the effects of
HEDP acid on adult mortality and offspring production of the freshwater
invertebrate Daphnia magna. The study reflects the lowest value
that is available for this endpoint.
additional long term toxicity study with HEDP-2Na to D. magna is
available which is regarded as not reliable. The pattern of mortality
and offspring production is erratic and the dose response curve is
the available information of acute toxicity to aquatic invertebrates
into account the registrant concluded the acute toxicity of HEDP acid to
aquatic invertebrates as 527 mg/L which can be calculated to be
equivalent to 754 mg/L HEDP Na4 salt. The
apparent NOEC of 0.1 mg HEDP Na2/L from this study would result in an
extraordinary acute to chronic ratio of >5000.
adult daphnia mortalities as well as the number of offspring per adult
show an erratic pattern. While at the nominal concentration of 0.3 mg/L
20% (1 individuum) of the adult test organisms died, no additional
mortalities were observed up to a nominal concentration of 10 mg/L. The
number of offspring per adult follows the same strange pattern. The raw
data show that the test solutions were prepared from a set of stock
solutions (10, 1, 0.1, 0.01 and 0.001 mg/L). There is an insufficient
level of detail to interpret what happened in the test and to clarify
whether potentially a mix up of stock solutions was the reason for the
erratic effect pattern. The results do not substantiate free of doubt a
NOEC of 0.1 mg/L. Therefore the study is disregarded.
data are available determining the toxicity of HEDP-4Na to aquatic
invertebrates, however the study with HEDP acid and D. magna is
of tests conducted on HEDP and its salts are directly comparable,
because the ionisation state will depend only on the pH of the test
medium. The counterion is not considered to contribute to effects in
aquatic invertebrates. At environmentally-relevant pH values, HEDP will
be ionised typically three times, and will form stable complexes with
value of 6.75 mg equivalent active acid/L may be directly read-across.
It is convenient to convert the result into units of mg HEDP-4Na salt/L.
d NOEC for HEDP 2809-21-4 is 6.75 mg/L, which is equivalent to a 28 d
NOEC value of 6.75 * 1.43 = 9.63 mg/L HEDP-4Na (CAS 3794-83-0)
Using: MW(HEDP-4Na)/MW(HEDP) =
293.96 / 206.03 = 1.43
a sub-chronic study with the eastern oyster Crassostrea virginica
with HEDP acid is available. This is a reliable study and also a
sensitive endpoint (shell growth), determining a 96 h EC50 (reported as
LC50) value of 130 mg active acid/L (reported as 81 ppm, the value has
been converted taking into consideration the density of the test
substance, i e. 1.6).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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