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EC number: 223-267-7
CAS number: 3794-83-0
Body weight was decreased 50-60% in animals given 40 mg/kg
bwt by s.c. injection. Calcium absorption by the small
intestine was significantly decreased (both sexes)while
total plasma calcium was slightly but significantly elevated
in females only. The rate of longitudinal bone growth could
not be determined since disodium HEDP interfered with
tetracycline binding in bone. The proximal tibial epiphyseal
plates were enlarged in both sexes, and the amount of
mineralised tissue present in the proximal tibial metaphyses
increased. There were mineralisation arrest lines in the
metaphyseal spongiosa, which possibly corresponded with the
daily s.c. injections of disodium HEDP.
Body weight was significantly decreased 30-40% in animals
given 360 mg disodium HEDP/kg bwt/d for 28 days. Calcium
absorption by the small intestine was decreased
significantly in both sexes (plasma calcium not reported),
with significant increases in growth plate thickness and the
percentage of mineralised tissue present in the proximal
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