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EC number: 223-267-7
CAS number: 3794-83-0
In a well-conducted acute dermal toxicity limit test, conducted
according to a protocol that was similar to OECD 402, but not to GLP,
5000 mg/kg bw of Dequest 2016 was applied to the skin of New Zealand
white rabbits (5/sex) under an occlusive dressing, for 24 hours. After
the 24 hour exposure period excess test substance was wiped off the test
site. Animals were then observed for 14 days for signs of toxicity, and
body weights were measured prior to dosing and on days 7 and 14. All
animals were examined macroscopically. One female died on Day 13.
However, macroscopic examination revealed signs of intestinal disease
that was not thought to be related to the test substance. All other
animals survived to the end of the observation period. In all surviving
animals there were some occurrences of oral and nasal discharge. Most
animals had severe dermal effects at the dose site (necrosis followed by
eschar formation and/or exfoliation of the eschar tissue), which
persisted throughout the observation period. Most animals had slight
weight losses at Days 7 and/or 14. The female that was found dead had
gross abnormalities suggestive of mucoid enteritis. Apart from the
presence of dermal lesions, there were no abnormal findings in the other
animals. The LD50 was determined to be >5000 mg/kg bw.
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