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EC number: 204-528-4
CAS number: 122-20-3
limited 104-week dietary study, no histological evidence of increased
liver foci was found in male rats in response to dietary administration
of 2% TIPA. In addition, the substance is not mutagenic and no
hyperplasia and/or pre-neoplastic lesions were observed in the oral
semichronic repeated dose toxicity study.
Based on the
results of a 104-week dietary study with 2% TIPA, the absence of
hyperplasia and/or pre-neoplastic in the oral semichronic repeated dose
toxicity study and the negative in vitro and in vivo genotoxicity
studies, TIPA is considered to be non-carcinogenic; therefore
classification according to EU Classification, Labelling and Packaging
of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 is not
A limited 104-week dietary study with 0 or
2% TIPA in the feed was conducted using 21 male Wistar rats per dose
(Yamamoto et al., 1989). Additional groups (28 animals/dose) were
co-treated with TIPA and 0.15% or 0.3% sodium nitrite (NaNO2). No
preneoplastic GST-P-positive foci were observed in the liver of TIPA or
TIPA and NaNO2 treated rats.
Furthermore, the substance is not mutagenic
and no hyperplasia and/or pre-neoplastic lesions were observed in the
oral semichronic repeated dose toxicity study with TIPA.
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