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Description of key information

Acute toxicity to fish

The results as presented by a BASF AG study from 1987 indicate that the test substance is not harmful to fish. The 96 -h LC50 value calculated as geometrical mean is 3158 mg/L. Results are supported by an acute toxicty test according to EU Method C.1 (Acute Toxicity for Fish) from Hüls (1997). In the limit-test no mortality was observed at 1000 mg/L (LC50 (96 h) >1000 mg/L, nominal confirmed by concentration control analytics). 


Long-term toxicity to fish

The long-term toxicity to fish is derived using the Acute-to-Chronic (ACR) approach. Based on the available 96-h LC50 of 3158 mg/L (BASF AG, 1987) a NOEC for the long-term toxicity to fish of 32 mg/L was derived.


Acute toxicity to invertebrates

The results as presented in a BASF AG study conducted in 1987 indicate that the test substance is with high probability not acutely harmful to aquatic invertebrates. The EC50 based on mobility was determined to be > 500 mg/L.

The results are supported by an acute toxicty test according to EU Method C.2 (Acute Toxicty for Daphnia) from Hüls (1997). The EC50 (48 h) was measured to be 857 mg/L (nominal, analytically verified). 


Long-term toxicity to aquatic invertebrates

The long-term toxicity on aquatic invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d NOEC for reproduction of Daphnia magna was derived using a trend analysis of the standardized workflow for ecotoxicological endpoints as provided by the Toolbox. The resulting 21-d NOEC was 27.5 mg/L. The Substance is within the applicability domain of the model. A robust study summary for this endpoint has been provided, which contains all relevant and required information. Therefore, a study on the long-term toxicity to aquatic invertebrates will not be performed.



Toxicity to aquatic algae

In order to determine the effects of 2-Propanol, 1,1',1''-nitrilotris- (CAS 122-20-3) on aquatic algae, there are experimental data from a study sponsored by Sasol Germany GmbH (1997; formerly Huels GmbH) available. In a test according to EU method C.3 with Desmodesmus subspicatus the 72-h ErC50 was determined to be 710 mg/L, the 72-h ErC10 was found to be 9.4 mg/L. In a supporting study by BASF (1990) the ErC50, recalculated from the fluorescence data, after 72 hours of exposure was determined to be > 100 mg/L. 


Toxicity to microorganisms

There is one valid study according to ISO 8192 available (BASF AG, 1981). The study resulted in an EC20 value of > 1995 mg/L. However the test was performed using industrial activated sludge. According to the "Guidance on information requirements and chemical safety assessment, chapter R.7b: Endpoint specific guidance, point R." industrial activated sludge is considered to be adapted to the test substance and the results can not be extrapolated to domestic activated sludge. Hence the results can not be used for a hazard assessment. 

Additional information