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EC number: 204-528-4
CAS number: 122-20-3
Acute toxicity data indicate low
toxicity: in rats the oral LD50 was 4000 mg/kg bw; in rabbits the dermal
LD50 (24h) was > 5000 mg/kg bw. Inhalation exposure for 8 hours to
vapour saturated with TIPA failed to cause any deaths in rats (LC50 was
not determined). A 3-hour inhalation exposure to 329-1070 mg/m3 TIPA
(aerosol) did not cause any mortality in mice.
rabbits survived the two-week observation period. No
signs of toxicity were observed in the rabbits.
A sample of triisopropanolamine, also known
as TIPA, was submitted for acute toxicological evaluation and definition
of industrial handling hazards. Toxicity tests were conducted on this
material as an 85% solution in distilled water. This is the final use
dilution. Eye, skin irritation and acute percutaneous absorption tests
were conducted on male or female New Zealand albino rabbits (Langshaw
Farms, Augusta, Michigan).
The potential of this material to produce
systemic toxicity when absorbed through the skin is low. In the acute
percutaneous absorption test 2 rabbits received 5000 mg/kg of the
material as an 85% aqueous solution; both rabbits survived the two-week
observation period. No signs of toxicity were observed in the rabbits.
Acute toxicity: oral
Several non-guideline oral acute toxicity
studies have been reported. In rats the oral LD50
value was determined to be 4000 mg/kg bw (BASF, 1966). At doses of 4000
mg/kg bw and higher, the following clinical signs were noted:
piloerection, high stepping gait, slight stagger, mouth discharge, eye
discharge, diarrhea, lateral and abdominal position, slight tremor,
partly dyspnoea, heavy stagger, eye and nose crusts, cramped hind limb,
ruffled fur smeared at the anogenital region, nose and mouth. Surviving
animals were very timid and recovered from day 4. At necropsy,
gastro-intestinal irritation and remaining substance in the stomach were
observed upon macroscopic examination in one animal of the highest dose
group (i.e. 6400 mg/kg bw). Other investigators established oral LD50
values in rats of 6500 mg/kg bw (Smyth et al., 1941) and 5994 mg/kg bw
Acute toxicity: inhalation
to its extremely low volatility, there is a lack of data documenting the
acute inhalation toxicity. As good quality data for the oral and dermal
route is available, in accordance with column 2 of REACH Annex VIII, a
study regarding the inhalation route is not required. One
limited report stated that whole-body exposure of rats to a saturated
test substance atmosphere (concentration not given) at 20°C for 8 hours
failed to cause any deaths, therefore no LC50 value has been determined
for this compound (BASF, 1966). In a study on respiratory irritation,
mice were exposed to aerosol concentrations of 329 - 1070 mg/m3 test
substance (Detwiler-Okabayashi, 1996). The 3-hour exposure caused
sensory irritation (immediate onset) and pulmonary irritation (delayed
onset). No mortality was observed. Post-exposure recovery of the
breathing frequency was moderate to good.
Acute toxicity: dermal
Female New Zealand White rabbits were
administered undiluted test material via dermal application under an
impervious cuff to their trunks for 24 hours, followed by a 14-day
recovery period. No evidence of systemic toxicity was reported and the
LD50 was greater than 5000 mg/kg bw. Only modest skin irritation was
evident following the 24 hours of exposure (Dow, 1980).
Based on the results of acute oral,
inhalation and dermal toxicity studies, the test substance does not need
to be classified according to the EU Classification, Labelling and
Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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