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EC number: 204-528-4
CAS number: 122-20-3
No sensitisation potential was reported in
guinea pigs upon dermal sensitisation and challenge with 22.9% TIPA in a
study similar to EPA guidelines. In a Schwartz-Peck Prophetic Patch test
with human volunteers, a lotion containing 1.1% TIPA was found not an
irritant, sensitiser, or phototoxin.
None of the guinea pigs challenged with the
test material revealed any signs of hyperemia or edema.
TIPA was given to 10 male Hartley albino
guinea pigs at 22.9% in water for 4 epicutaneous, semiocclusive
applications within a 10-day period (induction phase) (study according
to EPA guidelines). After a two week rest period, animals were dermally
challenged (uncovered) and the skin responses were recorded 24 and 48
hours post-application. No signs of sensitisation (i.e. hyperemia or
edema) were observed after TIPA exposure. Sensitisation was verified in
a positive control group (Dow, 1986).
In a human
Schwartz-Peck Prophetic Patch test the irritation, sensitisation and
phototoxicity of a lotion containing 1.1% TIPA was investigated in 98
volunteers (Research Testing Laboratories, 1975). Ninety-eight panelists
participated in a Schwartz-Peck Prophetic Patch test to determine the
irritation, sensitisation, and phototoxicity of a lotion product
containing 1.1 % TIPA. Open and occlusive patches were applied for 48 h,
and results were scored according to the International Contact
Dermatitis Research Group procedure with a 0-3+ scoring scale. After a
non-treatment period of approximately 14 days, a second set of open and
occlusive patches was applied and scored 48 h later. After scoring the
second occlusive patch reactions, these same test sites of all panelists
were irradiated for 1 minute with a Hanovia Tanette Mark I Lamp
(wavelength 5600 Angstroms). This site was scored for phototoxicity 48 h
later. No reactions were observed at the first or second open patch, the
first occlusive patch, or 48 h after irradiation. Four subjects had 1+
(weak, nonvesicular) reactions to the second occlusive patch, and one
subject had a 2+ (strong, edematous or vesicular) reaction to the second
occlusive patch. These reactions were not considered clinically
significant. The product was not an irritant, phototoxin, or sensitiser
under these test conditions.
No data are available. However, no positive
human data are available suggesting that the substance causes
respiratory tract sensitisation.
Based on the results of the dermal
sensitisation test, TIPA does not need to be classified according to the
EU Classification, Labelling and Packaging of Substances and Mixtures
(CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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