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EC number: 204-528-4
CAS number: 122-20-3
Polychromatic and normochromatic
The oral administration of the test
substance led to irregular respiration and piloerection at all three
dose levels after about 30 minutes. In the dose groups of 1,000 mg/kg
and 2,000 mg/kg squatting posture was additionally observed. After 2-4
hours these signs were not observed any longer.
The single administration of the vehicle in
a volume of 10 mL/kg body weight led to 2.4‰ polychromatic erythrocytes
containing micronuclei after the 24-hour sacrifice interval or to 2.7‰
after the 48-hour sacrifice interval.
After the single administration of the
highest dose of 2,000 mg/kg body weight, 3.4‰ polychromatic erythrocytes
containing micronuclei were found after 24 hours and 2.3‰ after 48
hours. In the two lower dose groups rates of micronuclei of about 2 ‰
(1,000 mg/kg group) and 3.2‰ (500 mg/kg group) were detected after a
sacrifice interval of 24 hours in each case.
With 21.4‰ the positive control substance
cyclophosphamide for clastogenicity, as expected, led to a clear
increase in the number of polychromatic erythrocytes containing mainly
small micronuclei at a dose level of 20 mg/kg body
weight. With 112.6‰ the positive control vincristine for spindle poison
effects also led to a clearly enhanced number of micronuclei cntaining
polychromatic erythrocytes with the expected amount of large
micronuclei, i.e. 15.6‰. The number of normochromatic erythrocytes
containing micronuclei did not differ to any appreciable extent in the
negative control or in the various dose groups at any of the sacrifice
Thus, the test substance Triisopropanolamin
did not lead to any increase in the rate of micronuclei. The number of
normochromatic or polychromatic erythrocytes containing small
micronuclei (d < D/4) or large micronuclei (d ≥ D/4) did not deviate
from the solvent control value at any of the sacrifice intervals. No
inhibition of erythropoiesis induced by the treatment of mice with
Triisopropanolamin was detected. The ratio of polychromatic to
normochromatic erythrocytes was always in the same range as that of the
control values in all dose groups .
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