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EC number: 201-224-3
CAS number: 79-77-6
Due to the lack of sufficient data regarding genetic toxicity in vitro,
data for the analogue substance mixed ionone isomers (CAS No. 8013-90-9)
were taken into account as it is a mixture of alpha- and beta-ionone. An
Ames test was performed according to OECD guideline 471 and no mutagenic
effects were found in bacteria strains S. typhimurium TA 1535, TA 1537,
TA 98 and TA 100 when concentrations up to 5000 µg/plate were used.
(Givaudan, 2004). Because of the structural similarities it can be
assumed, that also for beta-ionone alone no mutagenic effects in vitro
have to be expected.
alpha-ionone was tested in an in vitro chromosome aberration
assay with CH cell line B241 (Kasamaki et al. 1982). It showed
clastogenic effects at the test concentration of 25 mM. This very high
concentration does no correspond to the current guideline and
understanding of culture conditions. Acc
The genetic toxicity in vivo was analyzed in a micronucleus test (MNT),
which was performed in compliance with OECD Guideline 474 (BASF AG,
2003). Doses of 500 and 750 mg/kg bw given intraperitoneally lead to
evident signs of toxicity in the mice (poor general state, irregular
respiration, squatting posture) which were reversible after two days. At
the low dose (250 mg/kg bw), only minor signs of clincal toxicity were
observed after 2 and 4 hours of administration. As a result beta-ionone
did not have a chromosome-damaging (clastogenic) effect and there were
no indications of any impairment of chromosome distribution in the
course of mitosis (aneugenic activity) in bone marrow cells in vivo.
Due to negative results in studies performed according to OECD
Guidelines 471 and 474, no classification for genetic toxicity is
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