Registration Dossier
Registration Dossier
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EC number: 201-224-3 | CAS number: 79-77-6
Endpoint summary
Administrative data
Description of key information
Irritation:
- skin: not irritating (OECD 404)
- eye: not irritating (OECD 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Irritation to skin was analyzed in a study which was performed according to OECD Guideline 404 (BASF AG, 1992). 0.1 ml of pure substance was applied to clipped skin of 3 white rabbits for 4 h under semiocclusive condition. The resulting scores for erythema and edema were 0 at all observation times. Also, no irritant effects to eye could be detected in a study with 3 rabbits performed according to OECD Guideline 405 (BASF AG; 1992). Slight corneal opacity and iritis was observed after 24 hours of application and conjunctival irritation after 1, 24 and 48 hours, but all signs of irritation (including corneal opacity) were completely reversible within 72 hours of observation.
Justification for classification or non-classification
Due to results obtained in studies performed according to OECD Guidelines 404 and 405, no classification for skin and eye irritation is required.
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