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EC number: 201-224-3
CAS number: 79-77-6
Acute Toxicity:- oral: LD50 5300 kg/kg bw (mouse)- dermaL. LD50 > 2000 mg/kg bw (rat; analogy mixed isomers, CAS 8013-90-9)
To test for acute oral toxicity, pure beta-ionone was administered to a
group of five mice at three dose levels. The resulting LD50 was 5300
Furthermore, oral toxicity was evaluated in a 5-day test, where doses of
500, 1000, 2000, 4000 and 8000 mg/kg bw were administered to rats
(Hoffmann-LaRoche, 1975). No mortality was observed up to a dosage of
2000 mg/kg bw, but higher doses showed lethality. As a clinical sign of
toxicity, sedation was described at dosages of 500 mg/kg bw or higher.
Because 40% of the animal at the 4000 mg/kg dose group died after 5
applications within the 15 day period, one could assume that fewer
animals would have died after only one application. Thus,
the LD50 for rats was estimated as >4000 mg/kg bw.
To support this low acute oral toxicity, studies with the beta-ionone
isomer (CAS 14901 -07 -6) are used. In a study with rats, deaths
occurring within 24 h and within 10 days after dosing were recorded
(Givaudan, 1980). The calculated LD50 was 7120 +/- 1000 mg/kg bw for
deaths within 24 h and 3290 +/- 500 mg/kg bw after 10 days. In the same
study, the LD50 for acute oral toxicity in mice was found to be 2000 +/-
320 mg/kg bw after 10 days of observation. In another study with male
mice, the LD50 was found to be 5331 +/- 755 mg/kg bw (Hoffmann-LaRoche,
Due to the lack of data for acute dermal toxicity, results from the
mixed iosmers (CAS 8013 -90 -9) are taken into account. In an OECD 402
-study (Symrise, 1999) 10 Sprague Dawley rats (5/sex) had their fur
clipped on their backs and flanks. 2000 mg/kg bw of undiluted test
substance was applied and covered with gauze. After 24h the area was
wiped to removed the test material. All animals survived to the end of
the 14 -day observation period, the LD50 was found to be >2000 mg/kg bw.
Because of the structural similarities the same result for beta-ionone
(CAS 79 -77 -6) has to be expected.
Due to the resulting LD50 values for acute oral and acute dermal
toxicity of 5300 mg/kg bw and >2000 mg/kg bw, respectively, no
classification is required.
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