Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The sensitizing potential of beta-ionone was investigated in a human maximization test, where it was used at 2.5% in combination with the structural analogue alpha-ionone at 79.5% (CAS 127-41-3; Greif, 1967). When applied at 8% solution to 25 subjects none of them showed sensitizing reactions so that beta-ionone was classified as a non-sensitiser under the conditions of the study. This result was supported by numerous studies, where structural analogues of beta-ionone were tested negative in different animal studies like open epicutaneous tests or guinea pig maximization tests (Sharp, 1978; Takasago, 1999; Klecak, 1977, 1979, 1985; Ishihara, 1986). Because of the structural similarities it can be assumed, that the same results for beta-ionone can be expected.

Migrated from Short description of key information:
- skin: not sensitising (human)

Justification for classification or non-classification

Due to negative results in a study with humans and no evidence of sensitizing effects by supporting studies, where structural analogues have been tested, no classification for sensitization is required.