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EC number: 201-224-3
CAS number: 79-77-6
The sensitizing potential of beta-ionone was investigated in a human
maximization test, where it was used at 2.5% in combination with the
structural analogue alpha-ionone at 79.5% (CAS 127-41-3; Greif, 1967).
When applied at 8% solution to 25 subjects none of them showed
sensitizing reactions so that beta-ionone was classified as a
non-sensitiser under the conditions of the study. This result was
supported by numerous studies, where structural analogues of beta-ionone
were tested negative in different animal studies like open epicutaneous
tests or guinea pig maximization tests (Sharp, 1978; Takasago, 1999;
Klecak, 1977, 1979, 1985; Ishihara, 1986). Because of the structural
similarities it can be assumed, that the same results for beta-ionone
can be expected.
Due to negative results in a study with humans and no evidence of
sensitizing effects by supporting studies, where structural analogues
have been tested, no classification for sensitization is required.
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