Registration Dossier
Registration Dossier
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EC number: 201-224-3 | CAS number: 79-77-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The sensitizing potential of beta-ionone was investigated in a human maximization test, where it was used at 2.5% in combination with the structural analogue alpha-ionone at 79.5% (CAS 127-41-3; Greif, 1967). When applied at 8% solution to 25 subjects none of them showed sensitizing reactions so that beta-ionone was classified as a non-sensitiser under the conditions of the study. This result was supported by numerous studies, where structural analogues of beta-ionone were tested negative in different animal studies like open epicutaneous tests or guinea pig maximization tests (Sharp, 1978; Takasago, 1999; Klecak, 1977, 1979, 1985; Ishihara, 1986). Because of the structural similarities it can be assumed, that the same results for beta-ionone can be expected.
Migrated from Short description of key information:
Sensitisation:
- skin: not sensitising (human)
Justification for classification or non-classification
Due to negative results in a study with humans and no evidence of sensitizing effects by supporting studies, where structural analogues have been tested, no classification for sensitization is required.
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