Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The sensitizing potential of beta-ionone was investigated in a human maximization test, where it was used at 2.5% in combination with the structural analogue alpha-ionone at 79.5% (CAS 127-41-3; Greif, 1967). When applied at 8% solution to 25 subjects none of them showed sensitizing reactions so that beta-ionone was classified as a non-sensitiser under the conditions of the study. This result was supported by numerous studies, where structural analogues of beta-ionone were tested negative in different animal studies like open epicutaneous tests or guinea pig maximization tests (Sharp, 1978; Takasago, 1999; Klecak, 1977, 1979, 1985; Ishihara, 1986). Because of the structural similarities it can be assumed, that the same results for beta-ionone can be expected.

Migrated from Short description of key information:
- skin: not sensitising (human)

Justification for classification or non-classification

Due to negative results in a study with humans and no evidence of sensitizing effects by supporting studies, where structural analogues have been tested, no classification for sensitization is required.