Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Data from secondary source which meets basic scientific principles. Due to structural similarities of the registered substance trans-ß-ionone (CAS 79-77-6) and the used test substance ß-ionone (CAS 14901-07-6) the study data could be taken into account for assessment.
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Short term toxicity study on alpha-ionone, beta-ionone and citral
Author:
Givaudan
Year:
1980
Bibliographic source:
cited in the RIFM/FEMA database, location 43485
Report Date:
1980
Reference Type:
secondary source
Title:
Fragrance material review on alpha-ionone
Author:
Lalko J et al.
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S235–S240
Reference Type:
secondary source
Title:
A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
Author:
Belsito D et al.
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S130–S167

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Administration: daily, 5 times
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
- Administration: daily, 5 times
Doses:
no data
No. of animals per sex per dose:
10 animals/dose
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
7 120 mg/kg bw
Remarks on result:
other: +/- 1000 mg/kg bw for deaths occuring within 24 h
Sex:
not specified
Dose descriptor:
other: LD10
Effect level:
4 120 mg/kg bw
Remarks on result:
other: for deaths occuring within 24 h
Sex:
not specified
Dose descriptor:
other: LD90
Effect level:
12 300 mg/kg bw
Remarks on result:
other: for deaths occuring within 24 h
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 290 mg/kg bw
Remarks on result:
other: +/- 500 mg/kg bw for deaths occuring within 10 days
Sex:
not specified
Dose descriptor:
other: LD10
Effect level:
2 150 mg/kg bw
Remarks on result:
other: for deaths occuring within 10 days
Sex:
not specified
Dose descriptor:
other: LD90
Effect level:
5 040 mg/kg bw
Remarks on result:
other: for deaths occuring within 10 days
Mortality:
All deaths had occurred by 24 hours

Applicant's summary and conclusion