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EC number: 230-528-9
CAS number: 7173-62-8
Table 1: Dermal irritation of animal 1 and 2
2 additional test
* : necrosis covering half the patch area
Acute dermal irritation/corrosion of
N-Oleyl-1,3-diaminopropane (liquid) was investigated. 0.5mL of the test
substance were applied via a semiocclusive gauze patch to intact clipped
skin of one female New Zealand White rabbit and held in place for 4h. At
the end of the exposure period, residual test item was rinsed with tap
water. In an additional test 0.5mL were applied via a gauze patch to
intact clipped skin of another female New Zealand White rabbit and held
in place manually for only 3min without subsequent rinsing. Animals were
examined for signs of erythema and oedema at 1, 24, 48, 72h after patch
Calculation of Primary Irritation
Scores (PIS) as an average value over 24h, 48h and 72h was calculated
for each animal. This yielded values of 8 for both animals. Necrosis was
observed after 24h in both animals. Irritant effects were not reversible
and occurred as early as 3min after exposure (additional test) and
persisted. 1 Animal displayed weight loss during the observation period.
The symptoms after a contact period of both 4h or 3min required
euthanisation of the animals due to animal welfare reasons shortly after
the end of the 72h observation period.
Considering the reported data of this
irritation study it can be stated that the test item
N-Oleyl-1,3-diaminopropane showed severely irritant effects. According
to the EC criteria for classification and labelling requirements for
dangerous substances and preparations (Guidelines in Commission
Directive 2001/59/EC) the test item N-Oleyl-1,3-diaminopropane has to be
classified as corrosive and has obligatory labelling requirement for
The test on acute dermal
irritation/corrosion was performed under GLP and similar to
guideline OECD Guideline 404, EU Method B.4 and EPA OPPTS 870.2500
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