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EC number: 230-528-9
CAS number: 7173-62-8
The BCF is estimated using EPIsuite V4.0 using a measured log Kow.Although the calculated log Kow value of 7.69 (EPIsuite v4.0) for the unprotonated N-(hydrogenated tallow alkyl) trimethylendiamines (CAS no 68603-64-5) is clearly higher than the measured value of 1.5 (OECD 123), preference is given to base the calculated BCF on the measured log Kow value. The calculated BCF value of 4.6 indicates that alkyl-1,3-diaminopropanes have a low bioaccumulation potential. The low calculated BCF is considered to be realistic as the fraction of unprotonated amines will be very low in the environment.The alkyl-1,3-diaminopropanes are readily biodegradable and it is therefore unlikely that they will accumulate in the food chain. The predicted BCF value could even be lower, as the calculation of the BCF is not taking into account metabolism of the compound, e. g. by fish and other aquatic organisms.
The bioaccumulation potential of the diamines
is assessed by measuring the log Kow for two technical products. Diamines
are considered as difficult to test substances as they obtain certain
structural or physico-chemical properties, which can make its
measurement difficult. According to the guidance on regulatory compliant
Kow determination for surfactants a calculatedKow value will be the
first choice for surfactants. For the calculation approaches however it
is essential to consider the pH of the system (which determines the
ionisation of the surfactant). Because diaminesare for more than 99%
protonated under environmental conditions the calculation approach is
considered to have only a very limited predictive power for real life
conditions. Despite of that calculations have been performed using
EPI(v4.0). As none ofthe experimental methods is considered to very well
suited for determining the Kow of surface active chemicals tests have
been performed with the slow stirring method which is in theory is the
best approach. During these tests with three technical products the main
components of the product were quantified using LC/MS/MS analysis. The
figures presented in table 12c are average values.
Besides to that also the observed CMC values
are included in table 12c.
Table 12c Calculated and measured log Kow
values for three alkyl-1,3, diaminopropane technical products and the
calculated log BCF based on the measured log Kow.
Main components in the test substance (>1%)
Calculated Log Kow (protonated)
Calculated Log BCF (EPI v4.0)
Amines, N-9-octa-decenyl-, (Z) -
C18:1N primary amine
C18:0N primary amine
Amines, N-C16-18-alkyl (evennumbered) propane-1,3-diamine
C16 primary amine
C18 primary amine
The calculated BCF values could even be
lower, as the calculation of the BCF is not taking into account
metabolism of the compound, e. g. by fish and other aquatic organisms.
The BCF is estimated using EPIsuite V4.0
using a measured log Kow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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