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EC number: 267-956-0
CAS number: 67953-76-8
1: Effect of D2010 on growth and survival of D. magna after 28 days
(average of 4 replicates).
Nominal concentrations (mg/L as active acid)
Mortality of parents
Cumulative number of offspring
No. Alive (± SE)
4.3 ± 1.0
0.75 ± 0.5
3.2 ± 0.9
4.5 ± 0.5
4.2 ± 0.1
Result expressed as nominal concentration. Properties of the
test substance and evidence from other studies where
concentrations were measured indicate that nominal and measured concentrations are likely to be in good agreement.
Not enough information is reported on water
quality, however the frequency of water renewal suggests the parameters
to be in acceptable ranges.
standard error associated with the number of offspring has been reported
for each observation in time. However, it is not possible to add
standard errors for each observation time. Therefore due to the table
format (cumulative # of offspring) and lack of raw data the standard
error is not reported. The standard errors are very large and vary from
0.2 to 25. Given that the standard errors of the data at each point are
large, it is unlikely that number of offspring in the control and the
3.37 and 6.75 mg/L treatments would have been significantly different.
total average number of offspring does differ between the control, 3.37
and 6.75 mg/L concentrations. Nevertheless, when the values have been
compared at a each observation stage of the study (day of offspring
count) taking into consideration the standard error, the number of
offspring produced at each stage between the control, the 3.37 mg/L and
the 6.75 mg/L overlaps. This is true for all observations but the last
one at day 28. Should the raw data have been available it would have
been possible to make a more definitive evaluation. Therefore the NOEC
is considered to be 6.75 mg/L.
(28 d) NOEC 6.75 mg/L D. magna (r-a) (Monsanto, 1976).
The key or weight of evidence
studies with HEDP and its sodium salts can be reliably read-across to
other HEDP category members in accordance with the rationale outlined in
the ecotoxicological discussion.
The results of tests conducted
on HEDP and its salts are directly comparable, because the ionisation
state will depend only on the pH of the test medium. The counterion is
not considered to contribute to effects in fish. At
environmentally-relevant pH values, HEDP will be ionised typically three
times, and will form stable complexes with metal ions.
No reliable data are available
determining the toxicity of HEDP potassium salts to aquatic
invertebrates, however a reliable study with HEDP-H and D. magna
is available. A reliable
28 day NOEC value of 6.75 mg/L has been determined for the effects of
HEDP-H on adult mortality and offspring production of the freshwater
invertebrate Daphnia magna (Monsanto, 1976). The study
reflects the lowest value that is available for this endpoint.
A long-term toxicity study of
non-assignable reliability is available with HEDP-xNa to D. magna
(Henkel, 1984). However,
the pattern of mortality and offspring production is erratic and the
dose response curve is unusual. It appears that the concentration
of the test substance or bioavailability of essential nutrients (Ca) may
have posed a problem in the test; however it
was not possible to determine the causes of this, as the study provides
an insufficient level of detail. Therefore, the study has not been
included in the assessment.
Additionally, a sub-chronic
study with the eastern oyster Crassostrea virginica with HEDP-H
is available. This is a reliable study and also a sensitive endpoint
(shell growth), determining a 96 h EC50 (reported as LC50)
value of 130 mg active acid/L (reported as 81 ppm (equivalent to 81
mg/l), the value has been converted taking into consideration the
density of the test substance, ie. 1.6).
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