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EC number: 242-060-2
CAS number: 18172-67-3
Table 1: Individual and mean scores of
conjunctivae, iris and cornea
Time after treatment
Mean (24, 48 and 72 hours)
In an eye irritation study conducted
according to the OECD Guideline 405 and in compliance with GLP, three
male rabbits of the New Zealand White strain were exposed to 0.1 mL of
undiluted (-)-beta-pinene in one of the eyes while the other eye
corresponded to the control. The eyes were examined for irritation
scores at 1 hour and 1, 2, 3, 4, 7 and 8 days after dosing.
Instillation of (-)-BETA-PINENE resulted in
moderate redness of the conjunctivae associated with moderate to severe
chemosis in all treated animals after 1 hour of instillation. The
irritation completely resolved within 8 days. Mean individual scores at
24, 48 and 72 h after exposure for the 3 animals were 0, 0, 0 for cornea
score; 0, 0, 0 for iris score; 1, 1, 2 for conjunctivae score and 1.3,
1, 1 for chemosis score.
Under the test conditions, (-)-beta-pinene
is not classified as irritating to eyes according to Directive
67/548/EEC and CLP Regulation (EC) No 1272/2008.
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