Registration Dossier
Registration Dossier
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EC number: 242-538-0 | CAS number: 18727-04-3
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (14d) = 431 mg cobalt molybdenum oxide/kg feed (Gallus gallus) for pathology (read-across from cobalt chloride hexahydrate)
Key value for chemical safety assessment
Additional information
No data on toxicity to birds are available for cobalt hydrogen citrate. However, there are reliable data available for different analogue substances.
The environmental fate pathways and ecotoxicity effects assessments for cobalt metal and cobalt compounds is based on the observation that adverse effects to aquatic, soil- and sediment-dwelling organisms are a consequence of exposure to the bioavailable ion, released by the parent compound. The result of this assumption is that the ecotoxicology will be similar for all soluble cobalt substances used in the ecotoxicity tests. Therefore, data from soluble cobalt substances are used in the derivation of ecotoxicological and environmental fate endpoints, based on the cobalt ion.
Data on birds resulting in high quality information (expressed as Co) on several bird species (n=3) are summarized in the WHO CICAD (2006).
Dietary levels of 251 mg Co/kg feed, tested as cobalt chloride hexahydrate, caused a mortality of 10% in 14 day old broiler chickens, while concentrations of 116 mg Co/kg feed and higher decreased body weight and food intake significantly, the resulting concentrations of cobalt hydrogen citrate are 1061 and 490 mg cobalt hydrogen citrate/kg feed respectively (Diaz et al., 1994). Another study on 2-week old chickens showed significant adverse effects on growth at 100 mg Co/kg diet, tested as cobalt chloride, and significant mortality at 200 mg Co/kg diet, tested as cobalt chloride, after 5 weeks (with corresponding concentrations of 423 and 845 mg cobalt hydrogen citrate/kg diet). The latter study showed similar results at 200 mg Co/kg feed causing lesions and significant mortality at 500 mg Co/kg feed after 28 days in white peking ducklings, resulting in concentrations of 845 and 2,113 mg cobalt hydrogen citrate/kg feed, respectively
References:World Health Organization (2006). ConciseInternational Chemical Assessment Document 69.COBALT AND INORGANIC COBALT COMPOUNDS.
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