Diethyl phosphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: inhalation hazard test; no LD50 was derived

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Principles of method if other than guideline:

200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.

GLP compliance:

not specified

Test type:

other: Inhalation hazard test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diethyl phosphonate

EC Number:

212-091-6

EC Name:

Diethyl phosphonate

Cas Number:

762-04-9

Molecular formula:

C4H11O3P

IUPAC Name:

diethyl phosphonate

Test material form:

other: colourless liquid

Details on test material:

content not given
the substance is described as technically pur; colourless liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Fasting period before study: ca 16 hours
- Diet ad libitum:
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
no details given

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

ca. 7 h

Concentrations:

no data
inhalation hazard test

No. of animals per sex per dose:

5 males and 5 females at 20°C,
5 males and 5 females at 80°C

Control animals:

no

Details on study design:

200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: inhalation hazard test

Based on:

other: exposure at 20°C and at 80°C

Exp. duration:

7 h

Remarks on result:

other: The exposure was tolerated without signs of toxicity ; no rat died

Mortality:

no rat died

Clinical signs:

other: no rat showed clinical signs

Body weight:

normal body weight development

Gross pathology:

animals exposed at 20 °C showed no gross pathological changes
animals exposed at 80 °C showed mild swolen lungs at necropsy

Applicant's summary and conclusion

Executive summary:

200 L air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed in a 10 L vessel for a single period of 7 hours. The observation period was 14 days. Prior to treatment and weekly in the observation period the animals were weighed. At the end of the study animals were examined gross-phathologically. No signs of toxicity were evident during exposure. No macroscopic effects were found in the 20°C group at post mortem at the end of the observation period, while mild swelling of the lungs were seen in animals in the 80°C group.