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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: inhalation hazard test; no LD50 was derived

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
GLP compliance:
not specified
Test type:
other: Inhalation hazard test
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl phosphonate
EC Number:
212-091-6
EC Name:
Diethyl phosphonate
Cas Number:
762-04-9
Molecular formula:
C4H11O3P
IUPAC Name:
diethyl phosphonate
Test material form:
other: colourless liquid
Details on test material:
content not given
the substance is described as technically pur; colourless liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Fasting period before study: ca 16 hours
- Diet ad libitum:
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
no details given

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 7 h
Concentrations:
no data
inhalation hazard test
No. of animals per sex per dose:
5 males and 5 females at 20°C,
5 males and 5 females at 80°C
Control animals:
no
Details on study design:
200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: inhalation hazard test
Based on:
other: exposure at 20°C and at 80°C
Exp. duration:
7 h
Remarks on result:
other: The exposure was tolerated without signs of toxicity ; no rat died
Mortality:
no rat died
Clinical signs:
other: no rat showed clinical signs
Body weight:
normal body weight development
Gross pathology:
animals exposed at 20 °C showed no gross pathological changes
animals exposed at 80 °C showed mild swolen lungs at necropsy

Applicant's summary and conclusion

Executive summary:

200 L air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed in a 10 L vessel for a single period of 7 hours. The observation period was 14 days. Prior to treatment and weekly in the observation period the animals were weighed. At the end of the study animals were examined gross-phathologically. No signs of toxicity were evident during exposure. No macroscopic effects were found in the 20°C group at post mortem at the end of the observation period, while mild swelling of the lungs were seen in animals in the 80°C group.