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EC number: 247-426-5
CAS number: 26040-51-7
No animal died during the course of the study. There were no local or
systemic signs of reaction to treatment, following percutaneous
treatment with RC9927. All animals achived normal body weight gains
during the 14-day observation period. Necropsy on Day 15 revealed dark
thyroids, thymus, lungs and salivary glands, petechiae of the thymus
and/or abnormal gastrointestinal contents in the majority of animals.
However, these are common findings for rabbits at this laboratory and
were not considered to be related to treatment with the testmaterial.
Pale staining around the nares or occasional areas of exfoliation at the
dermal application site were also recorded for single animals.
Groups of 5 male and 5 female rats were administered a single dose of 2
ml of the test material per kg bw to the shaved intact site on the back
for 24 hours. The animals were observed for mortality, clinical signs
and body weight for 14 days. A complete necropsy was performed on each
Under the conditions of this study, the acute percutaneous median lethal
dosage (LD50) of the test substance was greater than 2 ml/kg (= 3.09
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