Registration Dossier
Registration Dossier
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EC number: 274-533-4 | CAS number: 70285-70-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The genetic toxicity classification of the target substance ADP (CAS 70285-70-0) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Consequently, based on the read-across (analogue approach, see attachment "ADP_70285-70-0_Readacross_Justification” in section 13) and the results from the source substances ATP, DI-Na (CAS 987-65-5) and AMP (CAS 61-19-8), it can be assumed that also the target substance ADP (CAS 70285-70-0) has no mutagenic activity on the applied bacterium tester strains.
ATP, DI-Na (CAS 987-65-5)
The reported data of the in vitro bacterial reverse mutagenicity assay (AMES test, OECD 471) show that under the experimental conditions applied, the test item did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used in presence or absence of metabolic activation. In conclusion, the test item ATP, DI-Na (CAS 987-65-5) has no mutagenic activity on the applied bacterial tester strains under the test conditions used in this study.
AMP (CAS 61-19-8)
The reported data of the in vitro bacterial reverse mutagenicity assay (AMES test, OECD 471) show that under the experimental conditions applied, the test item did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used in presence or absence of metabolic activation. In conclusion, the test item Adenosine-5’-monophosphate (AMP) (CAS Nr. 61-19-8) has no mutagenic activity on the applied bacterium tester strains under the test conditions used in this study.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attachment "ADP_70285-70-0_Readacross_Justification" in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, and E. coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- The reported data of this mutagenicity assay show that under the experimental conditions applied, ATP, Di-Na (CAS 987-65-5) did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used. In conclusion, the test item ATP, Di-Na has no mutagenic activity on the applied bacterium tester strains under the test conditions used in this study.
Based on the readacross, also the target substance ADP (CAS 70285-70-0) has no mutagenic activity on the applied bacterium tester strains. - Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attachment "ADP_70285-70-0_Readacross_Justification" in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, and E. coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- The reported data of this mutagenicity assay show that under the experimental conditions applied, the test item did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used. In conclusion, the test item Adenosine-5’-monophosphate (AMP) (CAS Nr. 61-19-8) has no mutagenic activity on the applied bacterium tester strains under the test conditions used in this study.
Based on readacross, also the target substance ADP (CAS 70285-70-0) has no mutagenic activity on the applied bacterium tester strains.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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