Adenosine 5'-(trihydrogen diphosphate), monopotassium salt

Endpoint summary

Description of key information

Based on read-across (analogue approach) from ATP, DI-Na (CAS 987-65-5) and AMP (CAS 61-19-8) (see attachment "ADP_70285-70-0_Readacross_Justification”) in section 13, available data indicate, that the target substance ADP (CAS 70285-70-0) should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).

 

ATP, DI-Na (CAS 987-65-5)

Algae: The acute toxicity of ATP, Di-Na (CAS no. 987-65-5) to the green alga Desmodesmus subspicatus was determined in a 72 hour static test according to OECD guideline 201. The median effect concentrations (EC50) of ATP, Di-Na on the green alga Desmodesmus subspicatus was estimated to be >100 mg/l nominal concentration after 72 h of exposure. The NOEC values were determined to be 100 mg/l nominal concentration after 72 h of exposure. The results of the test can be considered reliable without restriction.

 

Daphnia: The acute toxicity of ATP, Di-Na (CAS no. 987-65-5) to Daphnia magna was determined in a 48 hour semi-static test according to OECD guideline 202.The median effect concentrations (EC50) of ATP, Di-Na on Daphnia magna were estimated to be >42.8 mg/l and >43.8 mg/l measured concentration after 24 and 48 h of exposure, respectively. The NOEC values were determined to be 42.8 mg/l and 43.8 mg/l measured concentration after 24 and 48 h of exposure, respectively.The results of the test can be considered reliable without restriction.

 

Conclusion on classification: The environmental classification of ATP, Di-Na (CAS no. 987-65-5) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >42.8 mg/L (EC50 for aquatic invertebrates). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).

 

AMP (CAS 61-19-8)

Algae: The acute toxicity of Adenosine-5’-monophosphate (AMP) (CAS no. 61-19-8) to the green alga Desmodesmus subspicatus was determined in a 72 hour static test according to OECD guideline 201. The median effect concentrations (EC50) of Adenosine-5’-monophosphate on the green alga Desmodesmus subspicatus were estimated to be >100 mg/l nominal concentration after 72 h of exposure. The NOEC values were determined to be 100 mg/l nominal concentration after 72 h of exposure. The results of the test can be considered reliable without restriction.

Daphnia: The acute toxicity of Adenosine-5’-monophosphate (AMP) (CAS no. 61-19-8) to Daphnia magna was determined in a 48 hour static test according to OECD guideline 202. The median effect concentrations (EC50) of Adenosine-5’-monophosphate on Daphnia magna were estimated to be >93.4 mg/l and >81.6 mg/l measured concentration after 24 h and 48 h of exposure, respectively. The NOEC values were determined to be 93.4 mg/l and 81.6 mg/l measured concentration after 24 h and 48 h of exposure, respectively. The results of the test can be considered reliable without restriction.

 

Conclusion on classification: The environmental classification of Adenosine-5’-monophosphate (AMP) (CAS no. 61-19-8) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >81.6 mg/L (EC50 48 h for aquatic invertebrates). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).