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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: - Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The viscoelastic properties of the arterial vessels in workers in contact with cyanuric chloride (translation from russian)
Author:
Soboleva, L., P.;
Year:
1988
Bibliographic source:
Vrach Delo., Vol. 9, p. 103-105

Materials and methods

Study type:
medical monitoring
Endpoint addressed:
not applicable
Principles of method if other than guideline:
- measurement of the propagation velocity of puls wave along elastic and muscular arterial vessels
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material : Cyanuric chloride

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
- 38 worker of a cyanuric chloride producing plant were analyzed for 4 years for the viskoelastic properties of their aterial vessels and compared to a control group of 30 persons similar in composition concerning age and gender ratio and not in contact with the test item
- The survey started 3 months after launching of the production plant and was repeated twice a year
- additional analysis of excretion of L-DOPA, dopamin, adrenaline and noradrenaline
- in addition effects of a therapy in a hospital on the analyzed parameters are stated (treatments: medication with vasodilatory drugs and vitamine B12, thermal treatment and bathing)

Results and discussion

Results:
- the maximal working place concentration of 0.1 mg/cbm was periodically surpassed
- generalised an alteration of the visco elastic properties of the vessels of the workers was stated
- in general an rising excretion of L-DOPA and dopamine and a decrease in noradrenaline and adrenaline excretion was determined with increasing duration of exposure
- a rise of the frequency of hypertensic incidents in the workers is unclear in the report
- effects of the hospital therapy remains unclear
- no individual data was reported an the points of comparison are not totally clear in some comparisons

Applicant's summary and conclusion

Conclusions:
Under the conditions of the present study Cyanuric chloride leads to an alteration of the visco elastic properties of the vessels of the workers compared to a non exposed group. However, due to insufficient documentation (i.e. no individual data was presented) and methodological deficiences (i.e. confounding factors like smoking and dietary habits, body weight development, etc. are not reported) an assessment of the results is not possible.