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Short-term toxicity to aquatic invertebrates

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Description of key information

The read across substance isocyanuric acid (CAS no.: 108-80-5) (final hydrolysis product of the hydrolysis of cyanuric chloride) was tested for toxicity to aquatic freshwater invertebrates in a 48 h-static test according to OECD guideline 202. The EC50 (48 h) was assessed to be 1000 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1 000 mg/L

Additional information

Key study (97-0702-FGO_en):

The read across substance isocyanuric acid (CAS no.: 108-80-5) (final hydrolysis product of the hydrolysis of cyanuric chloride) was tested for toxicity to aquatic freshwater invertebrates in a 48 h-static test according to OECD guideline 202. The EC50 (48 h) and EC50 (24 h) was assessed to be 1000 mg/L and > 1000 mg/L. The maximum no-observable effect level concentration (NOECi) of Daphnia exposed to Isocyanuric acid for a period of 24 and 48 hours was determied to be >1000mg/L and 580 mg/L, respectively.

Supporting study (90 -0016 -DGO):

In the study 90-0016-DGO a read across approach was applied with the supporting substance 2-chlor-4, 6-dihydroxy-1,3,5-triazin, mono sodium salt (CAS no.: 32998-00-8), that is a hydrolysis product of the hydrolysis of cyanuric chloride. The influence of test item on invertebrates (Daphnia magna) was investigated according to EU-method C.2 and OECD guideline 202. Daphnids were exposed to the test item for 24 hours under static conditions. A limit concentration of 1000 mg/L was tested. The 24 h EC50 value was determined to be > 1000 mg/L. As worst-case value for chemical safety assessment an EC50 = 1000 mg/L was used.