Registration Dossier
Registration Dossier
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EC number: 203-614-9 | CAS number: 108-77-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- "Hyperactive cough" in occupational medicine
- Author:
- Alt, E.; Diller, W.;
- Year:
- 1 988
- Bibliographic source:
- Zbl. Arbeitsmeth., Vol 38, suppl. 2, p.22 - 26
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 203-614-9
- EC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 108-77-0
- Molecular formula:
- C3Cl3N3
- IUPAC Name:
- trichloro-1,3,5-triazine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - one test engineer, non-smoker, 47 years, only occasionally patrolling the production plant for 2,4,6-trichloro-1,3,5-triazine
- no memorable direct exposure with 2,4,6-trichloro-1,3,5-triazine - Clinical history:
- - allergic exanthem against Aspirin
- after a infection with fever a dry cough remained - Controls:
- not applicable
- Route of administration:
- inhalation
- Details on study design:
- - auscultation
- lung function test
- bronchoscopy
- acetylcholine provocation test
- RAST (radioallergosorbent test) for 2,4,6-trichloro-1,3,5-triazine
Results and discussion
- Results of examinations:
- - auscultation: normal
- lung function test: normal but slightly raised residual volume
- bronchoscopy: one site of inflammatory swelling
- acetylcholine provocation test: no resistance increase but strong urge to cough
- RAST (radioallergosorbent test) for 2,4,6-trichloro-1,3,5-triazine: positive
- complete decay of the dry cough after shifting the person to a different production plant
Applicant's summary and conclusion
- Conclusions:
- In the present case study a non smoking 47 year old engineer with a dry cough, working occasionally at a 2,4,6-trichloro-1,3,5-triazine production plant, was tested positive for specific IgE against 2,4,6-trichloro-1,3,5-triazine. Dislocation the person from the 2,4,6-trichloro-1,3,5-triazine production plant led to complete decay of the dry cough.
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